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KEY PAPERS


1) Stoyanovsky DA, Kapralov A, Huang Z, Maeda A, Osipov A, Hsia CJC, Ma L, Kochanek PM, Bayr H, Kagan VE. Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: Elimination of H2O2 coupled with intramolecular oxidation of nitroxides. Biochem and Biophys Res Com 399:139-143 (2010)

 

2) Shellington DK, Du L, Wu X, Exo J, Vagni V, Ma L, Janesko-Feldman K, Clark RSB, Bayir H, Dixon CE, Jenkins LW, Hsia CJC, Kochanek PM, Polynitroxylated pegylated hemoglobin:  A novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after  combined traumatic brain injury and hemorrhagic hypotension in mice Crit Care Med. 39(3):494-505 (2011)

  

3) Hsia CJC and Ma. L . A Hemoglobin-based Multifunctional Therapeutic: PNPH. Artificial Organs 36:215-220 (2012)

 

4) Ma L and Hsia C. Polynitroxylated Hemoglobin as a Multifunctional Therapeutic for Critical Care and Transfusion Medicine (Chapter 8, page 169-194). In book: Selected Topics in Nanomedicine, ed. TM Chang, World Science Publisher/Imperial College Press, Singapore/London (2013)

  

5) Hsia CJC, Thompson FM, Wang D, Ma L. Polynitroxylated Pegylated Hemoglobin (PNPH) - A Nanomedicine for Critical Care and Transfusion (Chapter 16, page 299-314). In: Hemoglobin-based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics, ed. Kim HW & Greenburg AG . Springer Verlag, Berlin/Heidelberg, Germany (2014).

 

6) Brockman EC, Bayir H, Blasiole B, Shein SL, Fink EL, DixonCE, Clark RSB, Vagni VA, Ma L, Hsia CJC, TishermanSA, Kochanek PM. Polynitroxylated Pegylated Hemoglobin Attenuates Fluid Requirements and Brain Edema in Combined Traumatic Brain Injury Plus Hemorrhagic Shock in Mice. J Cereb Blood Flow Metab Sep;33(9):1457-64. doi: 10.1038/jcbfm.2013.104 (2013). Free PMC Article     


7) Brockman EC, Jackson TC, Dixon CE, Bayɪr H, Clark RS, Vagni V, Feldman K, Byrd C, Ma L, Hsia C, Kochanek PM. Polynitroxylated Pegylated Hemoglobin-A Novel, Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to Whole Blood and Dose Response Evaluation. J Neurotrauma. Apr 1;34(7):1337-1350. doi: 10.1089/neu.2016.4656 (2017). Free PMC Article


8) Suyi Cao, Jian Zhang, Li Ma, Carleton J. C. Hsia, Raymond C. Koehler. Transfusion of Polynitroxylated Pegylated Hemoglobin Stabilizes Pial Arterial Dilation and Decreases Infarct Volume After Transient Middle Cerebral Artery Occlusion. J Am Heart Assoc. 6:e006505.

https://doi.org/10.1161/JAHA.117.006505 (2017). Free Article