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Publications
KEY PAPERS

1: Hsia CJC, Messerli SM, Miskimins WK. Can Anti-Metastatic Albumin-based

Superoxide Dismutase Mimetic Serve as a "Moonshot" Drug for Treatment for Brain

Tumors - From Medulloblastoma to Glioblastoma? Cell Biochem Biophys. 2019

Jun;77(2):121-122. doi: 10.1007/s12013-019-00869-2. Epub 2019 May 15. PubMed

PMID: 31093886.


2: Messerli SM, Schaefer AM, Zhuang Y, Soltys BJ, Keime N, Jin J, Ma L, Hsia CJC,

Miskimins WK. Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple

Negative Breast Cancer. J Oncol. 2019 Feb 28;2019:3253696. doi:

10.1155/2019/3253696. eCollection 2019. PubMed PMID: 30941174; PubMed Central

PMCID: PMC6420975.


3: Hsia CJC, Miskimins WK. Can Macromolecular Nitroxide Work as Extracellular

Superoxide Dismutase Mimetic in Cancer and Stroke Therapy? Cell Biochem Biophys.

2018 Dec;76(4):443-444. doi: 10.1007/s12013-018-0853-6. Epub 2018 Sep 6. PubMed

PMID: 30191451.


4: Cao S, Zhang J, Ma L, Hsia CJC, Koehler RC. Transfusion of Polynitroxylated

Pegylated Hemoglobin Stabilizes Pial Arterial Dilation and Decreases Infarct

Volume After Transient Middle Cerebral Artery Occlusion. J Am Heart Assoc. 2017

Sep 12;6(9). pii: e006505. doi: 10.1161/JAHA.117.006505. PubMed PMID: 28899897;

PubMed Central PMCID: PMC5634295.


5: Brockman EC, Jackson TC, Dixon CE, Bayɪr H, Clark RS, Vagni V, Feldman K, Byrd

C, Ma L, Hsia C, Kochanek PM. Polynitroxylated Pegylated Hemoglobin-A Novel,

Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to

Whole Blood and Dose Response Evaluation. J Neurotrauma. 2017 Apr

1;34(7):1337-1350. doi: 10.1089/neu.2016.4656. Epub 2017 Jan 13. PubMed PMID:

27869558; PubMed Central PMCID: PMC5385578.


6: Hsia CJ. Fast track approval of therapeutic blood substitutes. Artif Organs.

2014 Mar;38(3):179-81. doi: 10.1111/aor.12281. PubMed PMID: 24606130.


7: Brockman EC, Bayır H, Blasiole B, Shein SL, Fink EL, Dixon C, Clark RS, Vagni

VA, Ma L, Hsia CJ, Tisherman SA, Kochanek PM. Polynitroxylated-pegylated

hemoglobin attenuates fluid requirements and brain edema in combined traumatic

brain injury plus hemorrhagic shock in mice. J Cereb Blood Flow Metab. 2013

Sep;33(9):1457-64. doi: 10.1038/jcbfm.2013.104. Epub 2013 Jun 26. PubMed PMID:

23801241; PubMed Central PMCID: PMC3764379.


8: Manole MD, Kochanek PM, Foley LM, Hitchens TK, Bayır H, Alexander H, Garman R,

Ma L, Hsia CJ, Ho C, Clark RS. Polynitroxyl albumin and albumin therapy after

pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic

outcome. J Cereb Blood Flow Metab. 2012 Mar;32(3):560-9. doi:

10.1038/jcbfm.2011.165. Epub 2011 Nov 30. PubMed PMID: 22126915; PubMed Central

PMCID: PMC3293121.


9: Hsia CJ, Ma L. A hemoglobin-based multifunctional therapeutic:

polynitroxylated pegylated hemoglobin. Artif Organs. 2012 Feb;36(2):215-20. doi:

10.1111/j.1525-1594.2011.01307.x. Epub 2011 Sep 28. PubMed PMID: 21955160; PubMed

Central PMCID: PMC3653627.


10: Shellington DK, Du L, Wu X, Exo J, Vagni V, Ma L, Janesko-Feldman K, Clark

RS, Bayir H, Dixon CE, Jenkins LW, Hsia CJ, Kochanek PM. Polynitroxylated

pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited

fluid resuscitation after combined traumatic brain injury and hemorrhagic

hypotension in mice. Crit Care Med. 2011 Mar;39(3):494-505. doi:

10.1097/CCM.0b013e318206b1fa. PubMed PMID: 21169820; PubMed Central PMCID:

PMC3425360.


11: Exo JL, Shellington DK, Bayir H, Vagni VA, Janesco-Feldman K, Ma L, Hsia CJ,

Clark RS, Jenkins LW, Dixon CE, Kochanek PM. Resuscitation of traumatic brain

injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic

saline, and lactated Ringer's: Effects on acute hemodynamics, survival, and

neuronal death in mice. J Neurotrauma. 2009 Dec;26(12):2403-8. doi:

10.1089/neu.2009.0980. PubMed PMID: 19691424; PubMed Central PMCID: PMC2864460.


12: Kaul DK, Liu XD, Zhang X, Ma L, Hsia CJ, Nagel RL. Inhibition of sickle red

cell adhesion and vasoocclusion in the microcirculation by antioxidants. Am J

Physiol Heart Circ Physiol. 2006 Jul;291(1):H167-75. Epub 2006 Jan 27. PubMed

PMID: 16443674.


13: Mahaseth H, Vercellotti GM, Welch TE, Bowlin PR, Sonbol KM, Hsia CJ, Li M,

Bischof JC, Hebbel RP, Belcher JD. Polynitroxyl albumin inhibits inflammation and

vasoocclusion in transgenic sickle mice. J Lab Clin Med. 2005 Apr;145(4):204-11.

PubMed PMID: 15962839.